Thanks for the replies dudes!
Here's the full excerpt on the topic
If a bluff is designed to fold out better hands, it follows that at the micro's, you should almost never bluff in big pots. Why? Because there is a lot of money already in the pot. This is only possible if villain has shown to you that he has no intention of folding, because he feels his hand is strong. This means that his range is probably made up of more nut type hands than air or marginal hands.
Also, there is a thing called pot odds that you probably know (I remember knowing advanced concepts like "rangemerging" before actually grasping what valuebetting was). The bigger the pot, the less scary a big bet is for villain, because he has great actual pot odds, and almost no reversed implied odds, because your stack is already partly or largely in the pot. You have no weapons left.
The pots where you should bluff are the small ones, where you can feel villains hesitation: "Am I behind or ahead? Is it worth it to call this for this smallish pot?" Villains will talk themselves into folding small pots a lot more often. Why? Because your stack is a weapon, and the pot is a shield. A bet is more threatening when there's lots of money behind: your weapon looks dangerous compared to the shield. When the shield is big, your weapon doesn't look so scary.
@Pwll Know your enemy, but know yourself to.
Definitely gotta keep this in mind! I'm confident in my ability but sometimes find myself fighting to much for big pots which leads to spew